Potential for Real-Time Target Localization in Radiation Therapy Demonstrated 

Calypso® Medical Technologies, Inc., Investigators Present Progress at AAPM 47th Annual Meeting 

Seattle, WA – July 24, 2005 – Reports of scientific investigations of Calypso® Medical’s Calypso® 4D Localization System will be presented at the American Association of Physicists in Medicine (AAPM) 47th Annual Meeting. These abstracts discuss the Calypso® System with permanently implanted Beacon® Electromagnetic Transponders, which is designed to provide efficient, objective, accurate and continuous tumor location information for external beam radiation therapy without adding ionizing radiation.

Current methods of marking a tumor’s location for radiation therapy use less objective methods such as skin tattoos, snap shot x-ray images, or ultrasound images to align tumor targets prior to treatment. These methods lack the ability to continuously locate the target’s movement during treatment. Calypso® Medical Technologies’ investigational platform is expected to provide a way to position patients and continuously track the tumor’s position for external beam radiation therapy that is accurate, objective and efficient without an additional radiation dose. 

Calypso® Medical’s technology will be highlighted in five technical abstracts presented at the AAPM 47th Annual Meeting at the Washington State Convention & Trade Center in Seattle, July 24 – 28, and published simultaneously in the journalMedical Physics: 

• Accuracy and Precision of Implantable Radiofrequency Transponder Localization Measurements Conducted Using Multislice CT
  Presented by Lisha Zhang, PhD,
  Washington University, St Louis, MO;
  July 26, 4:00 PM - 4:45 PM; Exhibit Hall 4A
• Feasibility of Tracking Wireless AC Electromagnetic Transponders in Head and Neck Cancer Environment
  Presented by Timothy Mate, MD,
  Swedish Medical Center, Seattle, WA;
  July 26, 4:45 PM - 5:30 PM; Exhibit Hall 4A
• Dynamic Accuracy of An Implanted Wireless AC Electromagnetic Sensor for Guided Radiation Therapy; Implications for Real-Time Tumor Position Tracking
  Presented by Parag Parikh, MD,
  Washington University, St. Louis, MO;
  July 26, 4:45 PM - 5:30 PM; Exhibit Hall 4A
• Tracking Prostate Motion and Isocenter Offset During Treatment Using the Calypso® 4D Localization System
  Presented by Twyla Willoughby, M. D.
  Anderson Cancer Center-Orlando, Orlando, FL, and
  Steven Dimmer,
  Calypso® Medical Technologies;
  July 27, 1:15 PM - 3:05 PM; Room 6B 
• Guided Radiation Therapy: Organ Motion Tracking with Implanted AC Electromagnetic Transponders
  Presented by J. Nelson Wright,
  Calypso® Medical Technologies;
  July 27, 3:30 PM - 5:00 PM; Room 6B

The system will be available for demonstration viewing at two booths during the meeting: Calypso® Medical (No. 217), and Philips Radiation Oncology Systems (No. 801). 

Calypso® Medical recently raised $44 million in venture capital financing and is continuing clinical studies with its investigational device, which is not yet for sale, in leading cancer centers for prostate application.

20050724_aapm.pdf